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. 2021 Sep 27;12:5659. doi: 10.1038/s41467-021-25902-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Shown are the top 20 genes that correlate with β-amyloid (a) and tau (b) burden in NPH biopsies (FDR adjusted using the Benjamini–Hochberg procedure across all genes in the transcriptome—dotted line is FDR = 0.1; see Supplementary Data 1 for the full list; all correlations are Spearman’s correlations with two-sided significance). c A two-sided Fisher’s exact test confirmed that microglia-specific genes are overrepresented among the genes that individually passed our FDR threshold using human single-nucleus RNA-seq data²¹ (c shows Bonferroni adjusted p values; dotted line = p value of 0.05; See Supplementary Data 1 for numerical values).