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. 2021 Sep 27;11:19128. doi: 10.1038/s41598-021-98541-4

Figure 1.

Figure 1

Ability of SUN1 to block HIV-1 and other retroviruses. Human HT1080 fibrosarcoma cells stably expressing wild type SUN1-FLAG or containing the empty vector LPCX were challenged with increasing amounts of HIV-1, HIV-1-G208R, HIV-2, SIVmac, FIV, BIV, EIAV, and B-MLV expressing GFP as a reporter. Forty-eight hours post-infection, the percentage of GFP-positive cells was measured using a flow cytometer. Experiments were repeated at least three times and a representative experiment is shown. Fold differences in restriction are shown as the ratio of the area under the curve of the SUN variant to the empty vector pLPCX. Fold values greater than 2 are shown.