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. 2021 Sep 27;4:1133. doi: 10.1038/s42003-021-02662-5

Fig. 5. Disruption of extracellular matrix and actin cytoskeleton impacts interstitial viscoelasticity.

Fig. 5

a Top row: Brillouin shift of a P14 ovary when treated with CTK, which digests collagen matrix. CTK leads to a clear increase in the interstitial space (blue) between the primordial follicles at the cortex. Bottom row: Corresponding BLT maps. Scale bar = 40 μm. b Top row: Brillouin shift of a P14 ovary when treated with cytochalasin D, a pharmacological inhibitor that disrupts actin cytoskeleton. Lower row: Corresponding BLT maps showing that a disruption of actin cytoskeleton leads to higher BLT (black arrow) and decreased elasticity of the interstitial tissues. Scale bar = 40 μm. Time denotes hh:mm.