Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 28;7:89. doi: 10.1038/s41421-021-00321-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Using GSEA to analyze expressed genes from CD3E⁺CD8A⁺CD4⁻ clusters of top 20 TCR paired scRNA-seq data, 2 metabolism-related gene sets significantly upregulated in Follow-up group comparing with HD group (n = 7 in Follow-up group, n = 6 in HD group), and b a fatty acid metabolic gene set significantly upregulated in Late Follow-up group vs. HD group analysis (n = 4 in Late Follow-up group, n = 6 in HD group). NES, normalized ES; FDR, false discovery rate; NOM p, normalized p value. c Distribution of each group in CD8A⁺GZMK⁺ T effector memory subset. d Pseudo-time analysis of top 20 T cell clones from Discharged and Late Follow-up paired samples. Upper panel, CD8A⁺GZMK⁺ Tem subset of combined Discharged and Late Follow-up samples. The arrows indicate the cells’ differentiation trajectories from the beginning to the end; Lower panel, separated Discharged and Late Follow-up groups in CD8A⁺GZMK⁺ Tem subset (n = 3 per group). e Pseudo-time analysis of top 20 T cell clones from Discharged and Late Follow-up paired samples. Left panel, distribution of CD8A⁺CXCR5⁺ Tcm subset; right panel, only the Late Follow-up samples contributed in CD8A⁺CXCR5⁺ Tcm subset (n = 3 per group). DC, Discharged group; FU, Follow-up group; HD, Healthy Donor group; Tcm, central memory T cells; Tem, effector memory T cells.