Fig. 2. Inhibition of Aurora A and FLT3 in AML cell lines.
a Inhibition of phospho-TACC3 (S558) and phospho-Aurora A (T288) by different concentrations of CCT245718 in MV-4-11 and MOLM-13 cell lines following two-hour treatment. Total TACC3 and total Aurora A are shown as loading controls. b Inhibition of phospho-ERK and phospho-STAT5 by different concentrations of CCT245718 in both MV-4-11 and MOLM-13 cell lines following 2-h treatment.