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. 2021 Aug 26;125(7):966–974. doi: 10.1038/s41416-021-01527-2

Fig. 5. CCT245718 induces apoptosis in AML cell lines.

Fig. 5

a CCT245718 induces activation of caspase 3, cleavage of PARP and downregulation of survivin. MOLM-13 and MV-4-11 cells were treated with different concentrations of CCT245718 and MLN518 for 48 h. Levels of cleaved PARP, cleaved-caspase 3 and survivin were determined by western blotting. GAPDH was used as a loading control. b, c CCT245718 treatment enhances Annexin V/PI staining. MV-4-11 and MOLM-13 cells were treated with different concentrations of CCT245718 and MLN518 for 48 h. Cells were stained with FITC-labelled Annexin V/PI and analysed through FACS.