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CCT245718 overcomes TKD resistance in AML cell line.
| Cell Line | GI50 µM | |
|---|---|---|
| MLN518 | CCT245718 | |
| MOLM-13 | 0.103 ± 0.072 (n = 4) | 0.195 ± 0.048 (n = 4) |
| MOLM-13-Res | 1.162 ± 0.081 (n = 4) | 0.277 ± 0.078 (n = 5) |
| Fold difference | 11.3 | 1.42 |
GI50 values of MLN518 and CCT245718 in MOLM-13 and MOLM-13-Res cell lines in a 3-day MTS proliferation assay.
