Table 1.
The association between BDNF Val/Met polymorphism with lipid profiles and atherogenic indices in T2DM patients.
| BDNF Val/Met polymorphism | P-value | |||
|---|---|---|---|---|
| Val/Val | Val/Met | Met/Met | ||
| Age (year) | 54.20 ± 6.28 | 53.91 ± 6.97 | 53.56 ± 6.19 | 0.71 |
| Sex (male) N% | 155(58.5%) | 81(30.6%) | 29(10.9%) | 0.11 |
| Cigarette smoking (yes) N% | 76 (58.5%) | 37 (28.5%) | 17 (13.1%) | 0.12 |
| Alcohol consumption (no) N% | 355 (55%) | 229 (35.4%) | 62 (9.6%) | 0.34 |
| Familial history of diabetes (yes) N% | 296 (54.9%) | 186 (34.5%) | 57 (10.6%) | 0.42 |
| Glucose-lowering medication |
297 (53.9%) 69 (59.5%) |
197 (35.8%) 38 (32.8%) |
57 (10.3%) 9 (7.8%) |
0.48 |
| Metformin and glybenclamid N% | ||||
| Other medications N% | ||||
| Supplementation use (yes) | 364 (55%) | 232 (35%) | 66 (10%) | 0.45 |
| Total energy intake, kcal/day | 2606.74 ± 1030.58 | 2627.05 ± 918.05 | 2537.43 ± 865.26 | 0.80 |
| BMI (kg/m2) | 29.19 ± 4.61 | 29.78 ± 4.86 | 29.38 ± 3.86 | 0.30 |
| WC (cm) | 92.67 ± 10.90 | 92.70 ± 10.61 | 92.62 ± 10.21 | 0.99 |
| HDL (mg/dl) | 54.95 ± 13.40 | 54.66 ± 12.11 | 55.83 ± 11.32 | 0.80 |
| LDL (mg/dl) | 109.43 ± 34.33 | 112.48 ± 37.13 | 116.50 ± 38.50 | 0.27 |
| LDL/HDL | 3.03 ± 13.16 | 2.11 ± 0.67 | 2.12 ± 0.65 | 0.48 |
| TC (mg/dl) | 193.06 ± 65.66 | 199.80 ± 75.98 | 199.72 ± 66.06 | 0.46 |
| TG (mg/dl) | 183.77 ± 106.1 | 179.10 ± 103.24 | 192.46 ± 138.80 | 0.67 |
| Leptin (ng/ml) | 24.28 ± 13.55 | 27.67 ± 16.54 | 23.01 ± 14.18 | 0.16 |
| Ghrelin (ng/ml) | 2.15 ± 1.18 | 2.37 ± 1.30 | 2.33 ± 1.21 | 0.41 |
| AIP | 0.47 ± 0.23 | 0.46 ± 0.24 | 0.45 ± 0.27 | 0.82 |
| AC | 2.68 ± 1.51 | 2.81 ± 1.62 | 2.64 ± 1.17 | 0.54 |
| CRI.II | 2.06 ± 0.69 | 2.11 ± 0.67 | 2.12 ± 0.65 | 0.63 |
| CRI-I | 3.80 ± 1.67 | 3.83 ± 1.46 | 3.51 ± 1.05 | 0.32 |
| FRAP (mmol Fe2+/100 g) | 18.17 ± 13.41 | 17.35 ± 7.72 | 16.95 ± 6.62 | 0.56 |
| TRAP (mmol TE/kg) | 9.68 ± 5.56 | 9.75 ± 5.62 | 8.65 ± 3.70 | 0.32 |
| TEAC (mmol TE/kg) | 8.63 ± 4.30 | 8.63 ± 4.14 | 7.98 ± 3.09 | 0.49 |
| ORAC (µmol TE/100 g) | 30,553.29 ± 16,659.94 | 29,889.21 ± 12,158.26 | 29,602.80 ± 10,295.74 | 0.81 |
Data are presented as mean ± standard deviation (SD).
BMI body mass index, HDL-c high density lipoprotein cholesterol, LDL-c low density lipoprotein cholesterol, TG triglyceride, CRP C-reactive protein, PTX3 pentraxin-3, IL18 interleukin 18, TAC total antioxidant capacity, SOD superoxide dismutase, PGF2α prostaglandinF2α, FRAP ferric reducing ability of plasma, TRAP total reactive antioxidant potential, TEAC trolox equivalent antioxidant capacity, ORAC oxygen radical absorbance capacity, AIP log (TG/HDL), AC (TC-HDL)/HDL, CRI.II (LDL/HDL), CRI-I (TC/HDL).