Table 6.
The interaction of BDNF Val/Met polymorphism and TEAC on anthropometric indices, lipid profile and atherogenic indices.
| Variable | Allele | High adherence of TEAC | P | ||
|---|---|---|---|---|---|
| β | 95% CI | ||||
| BMI | Crud | Met/Met | − 7.09 | − 13.77 to − 0.24 | 0.04 |
| Val/Met | − 1.82 | − 6.02 to 2.38 | 0.39 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 1.60 | − 0.85 to 4.05 | 0.20 | |
| Val/Met | 1.31 | − 0.19 to 2.83 | 0.08 | ||
| Val/Val | Reference | ||||
| WC | Crud | Met/Met | − 20.43 | − 57.26 to 16.40 | 0.27 |
| Val/Met | 22.44 | − 0.52 to 45.42 | 0.05 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 3.15 | − 2.40 to 8.70 | 0.26 | |
| Val/Met | 2.31 | − 1.13 to 5.76 | 0.18 | ||
| Val/Val | Reference | ||||
| HDL | Crud | Met/Met | − 7.09 | − 13.77 to − 0.24 | 0.04 |
| Val/Met | − 1.82 | − 6.02 to 2.38 | 0.39 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 6.03 | − 12.64 to 0.56 | 0.07 | |
| Val/Met | − 5.67 | − 5.79 to 2.41 | 0.41 | ||
| Val/Val | Reference | ||||
| LDL | Crud | Met/Met | − 5.99 | − 24.91 to 12.93 | 0.53 |
| Val/Met | − 1.65 | − 13.43 to 10.11 | 0.78 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 1.42 | − 20.29 to 17.44 | 0.88 | |
| Val/Met | − 1.30 | − 13.02 to 10.41 | 0.82 | ||
| Val/Val | Reference | ||||
| TC | Crud | Met/Met | − 20.43 | − 57.26 to 16.40 | 0.27 |
| Val/Met | 22.44 | − 0.52 to 45.42 | 0.05 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 17.15 | − 54.06 to 19.75 | 0.36 | |
| Val/Met | 26.39 | 3.40 to 49.38 | 0.02 | ||
| Val/Val | Reference | ||||
| TG | Crud | Met/Met | − 30.82 | − 88.36 to 26.71 | 0.29 |
| Val/Met | 53.51 | 17.80 to 89.22 | 0.003 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 32.04 | − 90.16 to 26.08 | 0.28 | |
| Val/Met | 55.85 | 19.85 to 91.84 | 0.002 | ||
| Val/Val | Reference | ||||
| AIP | Crud | Met/Met | 0.005 | − 0.12 to 0.13 | 0.94 |
| Val/Met | 0.105 | 0.02 to 0.18 | 0.01 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 0.002 | − 0.13 to 0.12 | 0.98 | |
| Val/Met | 0.10 | 0.02 to 0.18 | 0.009 | ||
| Val/Val | Reference | ||||
| AC | Crud | Met/Met | 0.03 | − 0.77 to 0.83 | 0.93 |
| Val/Met | 0.51 | 0.01 to 1.02 | 0.04 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 0.02 | − 0.78 to 0.82 | 0.96 | |
| Val/Met | 0.55 | 0.05 to 1.06 | 0.03 | ||
| Val/Val | Reference | ||||
| LDL/HDL.CRI.II | Crud | Met/Met | 0.10 | − 0.25 to 0.47 | 0.55 |
| Val/Met | − 0.04 | − 0.26 to 0.17 | 0.69 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 0.15 | − 0.20 to 0.50 | 0.39 | |
| Val/Met | − 0.05 | − 0.27 to 0.16 | 0.64 | ||
| Val/Val | Reference | ||||
| TC/HDL.CRI.I | Crud | Met/Met | 0.25 | − 0.58 to 1.09 | 0.55 |
| Val/Met | − 0.04 | − 0.56 to 0.46 | 0.86 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 0.22 | − 0.61 to 1.06 | 0.60 | |
| Val/Met | − 0.03 | − 0.54 to 0.48 | 0.91 | ||
| Val/Val | Reference | ||||
Val/Val genotype is considered as a reference. Low adherence of DTAC is considered as a reference. Generalized linear model; crude model and adjusted model Age, physical activity, sex, smoking, alcohol, energy intake, lipid, and glucose-lowering medicines, and family history of diabetes, as covariates. Bold values denote statistical signifcance at the P < 0.05 level.
TEAC trolox equivalent antioxidant capacity, CI confidence interval, AIP (Atherogenic index of plasma): log(TG/HDL), AC (Atherogenic coefficient): (TC-HDL/HDL), CRI-II (Castelli s risk index): LDL/HDL, CRI-I (Castelli s risk index): TC/HDL, TC total cholesterol, TG triglyceride, HDL high density lipoprotein, LDL low density lipoprotein, WC waist circumference.