Table 7.
The interaction of BDNF Val/Met polymorphism and TRAP on anthropometric indices, lipid profile and atherogenic indices.
| Variable | Allele | High adherence of TRAP | |||
|---|---|---|---|---|---|
| β | 95% CI | P | |||
| BMI | Crud | Met/Met | 0.87 | − 1.61 to 3.36 | 0.49 |
| Val/Met | 1.20 | − 0.32 to 2.73 | 0.12 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 0.81 | − 1.66 to 3.29 | 0.52 | |
| Val/Met | 1.81 | − 0.33 to 2.69 | 0.12 | ||
| Val/Val | Reference | ||||
| WC | Crud | Met/Met | 0.88 | − 4.86 to 6.63 | 0.76 |
| Val/Met | 3.75 | 0.20 to 7.29 | 0.03 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 0.93 | − 4.66 to 6.53 | 0.74 | |
| Val/Met | 3.36 | − 0.07 to 6.80 | 0.05 | ||
| Val/Val | Reference | ||||
| HDL | Crud | Met/Met | − 3.58 | − 10.40 to 3.23 | 0.30 |
| Val/Met | − 3.86 | − 8.06 to 0.34 | 0.07 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 3.16 | − 9.83 to 3.49 | 0.35 | |
| Val/Met | − 3.71 | − 7.80 to 0.38 | 0.07 | ||
| Val/Val | Reference | ||||
| TC | Crud | Met/Met | − 18.56 | − 55.53 to 18.40 | 0.32 |
| Val/Met | 34.93 | 12.10 to 57.76 | 0.003 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 18.29 | − 55.35 to 18.76 | 0.33 | |
| Val/Met | 37.20 | 14.38 to 60.03 | 0.001 | ||
| Val/Val | Reference | ||||
| TG | Crud | Met/Met | − 33.52 | − 91.54 to 24.48 | 0.25 |
| Val/Met | 63.78 | 28.09 to 99.46 | < 0.001 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 37.97 | − 96.61 to 20.67 | ||
| Val/Met | 65.28 | 29.36 to 101.20 | < 0.001 | ||
| Val/Val | Reference | ||||
| LDL | Crud | Met/Met | 1.37 | − 17.70 to 20.46 | 0.88 |
| Val/Met | 1.39 | − 10.36 to 13.14 | 0.81 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 5.53 | − 13.50 to 24.56 | 0.56 | |
| Val/Met | 1.21 | − 10.46 to 12.90 | 0.83 | ||
| Val/Val | Reference | ||||
| AIP | Crud | Met/Met | − 0.01 | − 0.14 to 0.11 | 0.85 |
| Val/Met | 0.16 | 0.07 to 0.24 | < 0.001 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 0.02 | − 0.15 to 0.11 | 0.76 | |
| Val/Met | 0.16 | 0.08 to 0.24 | < 0.001 | ||
| Val/Val | Reference | ||||
| AC | Crud | Met/Met | − 0.12 | − 0.93 to 0.68 | 0.76 |
| Val/Met | 0.88 | 0.38 to 1.38 | 0.001 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 0.15 | − 0.96 to 0.65 | 0.71 | |
| Val/Met | 0.89 | 0.39 to 1.39 | < 0.001 | ||
| Val/Val | Reference | ||||
| LDL/HDL.CRI.II | Crud | Met/Met | 0.14 | − 0.21 to 0.51 | 0.42 |
| Val/Met | 0.09 | − 0.13 to 0.31 | 0.41 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | 0.19 | − 0.15 to 0.55 | 0.27 | |
| Val/Met | 0.07 | − 0.14 to 0.29 | 0.48 | ||
| Val/Val | Reference | ||||
| TC/HDL.CRI.I | Crud | Met/Met | − 0.25 | − 1.10 to 0.60 | 0.56 |
| Val/Met | − 0.21 | − 0.72 to 0.30 | 0.41 | ||
| Val/Val | Reference | ||||
| Adjusted | Met/Met | − 0.23 | − 1.09 to 0.61 | 0.58 | |
| Val/Met | − 0.21 | − 0.73 to 0.30 | 0.41 | ||
| Val/Val | Reference | ||||
Val/Val genotype is considered as a reference. Low adherence of DTAC is considered as a reference. Generalized linear model; crude model and adjusted model Age, physical activity, sex, smoking, alcohol, energy intake, lipid, and glucose-lowering medicines, and family history of diabetes, as covariates. Bold values denote statistical signifcance at the P < 0.05 level.
TRAP total reactive antioxidant potential, CI confidence interval, AIP (Atherogenic index of plasma): log(TG/HDL), AC (Atherogenic coefficient): (TC-HDL/HDL), CRI-II (Castelli s risk index): LDL/HDL, CRI-I (Castelli s risk index): TC/HDL, TC total cholesterol, TG triglyceride, HDL high density lipoprotein, LDL low density lipoprotein, WC waist circumference.