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. 2021 Sep 27;11:19130. doi: 10.1038/s41598-021-98544-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of serum starvation-induced genes (SIGs) in TCGA-HNSCC patients. The expression of 21 genes that showed significant changes in expression by serum starvation and their relative expression levels in TCGA-HNSCC patients were determined in primary tumors and solid normal tissues. (A) Box plots of the expression of 11 genes (AGR2, BST2, CALR, CD22, DDIT3, FOXA2, HSPA5, PIWIL4, PYCR1, SGK3, and TRIB3) that have been up-regulated more than two-fold. (B) Box plots of the expression of 10 genes (ATOH8, AXIN2, BNIP3, CCL2, CDKN2C, CNTN1, EGLN3, ID2, SERPINB3, and S100A8) that were down-regulated by more than 50%. * P < 0.05. (C) Heat map of 21 SIG expression profiles. Colors from blue to red indicate low to high expression levels.