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. 2021 Sep 27;11:19130. doi: 10.1038/s41598-021-98544-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Function and protein–protein interaction analysis of SIGs. (A) A list of the top 8 significant GO terms determined by GO enrichment analysis of 21 selected genes. BP, biological process; CC, cellular composition; MF, molecular function. (B) List of molecular pathways determined by KEGG pathway enrichment analysis of 21 selected genes. (C) Proteins encoded by 21 genes extracted using 7 keywords were subjected to PPI network analysis. Up-regulated genes are shown in red. Down-regulation is shown in blue, and gray indicates genes whose expression did not change under serum starvation.