Table 1.

Platelet count polygenic risk score and correlation with human diseases and quantitative traits.

Trait	Iceland			UK			Combined
	E	P	nAff/nCon	E	P	nAff/nCon	E (95% CI)	P	Phet
AS	0.179	0.002	373/139,426	0.322	5.2 × 10−15	612/407,963	0.274 (0.208, 0.340)	3.2 × 10−16	0.044
Hypertension	0.021	0.017	32,026/110,632	0.020	4.4 × 10−6	77,566/331,087	0.020 (0.013, 0.028)	2.3 × 10−7	0.92
RA	0.129	4.3 × 10−7	1772/136,368	0.098	5.7 × 10−10	4001/404,652	0.107 (0.080, 0.133)	2.1 × 10−15	0.32
MPN	0.237	0.0017	180/141,889	0.209	0.00011	348/406,981	0.218 (0.132, 0.305)	6.6 × 10−7	0.76
BPH	0.018	0.2	9346/42,591	0.041	5.6 × 10−8	21,067/166,609	0.036 (0.023, 0.049)	7.0 × 10−8	0.15
Trait	Beta	P	n	Beta	P	n	Beta (95% CI)	P	Phet
PLT	0.228	2.9 × 10−1558	139,489	0.326	3.8 × 10−6978	397,495	0.295 (0.292, 0.298)	3.9 × 10−8334	5.1 × 10−531
MPV	−0.201	1.2 × 10−675	136,560	−0.192	1.2 × 10−1865	397,490	−0.194 (−0.198, −0.190)	2.4 × 10−2538	1.9 × 10−5
WBC	0.059	7.6 × 10−116	140,123	0.082	1.2 × 10−463	397,495	0.075 (0.072, 0.078)	2.3 × 10−566	1.0 × 10−31
Lymphocyte count	0.047	3.4 × 10−73	132,215	0.066	3.3 × 10−300	396,820	0.060 (0.057, 0.063)	1.3 × 10−363	1.6 × 10−9
Basophil count	0.027	4.2 × 10−64	131,881	0.026	3.2 × 10−60	396,820	0.026 (0.024, 0.029)	2.2 × 10−122	0.66
Eosinophil count	0.043	6.6 × 10−61	131,889	0.061	7.2 × 10−251	396,820	0.055 (0.052, 0.058)	8.7 × 10−303	1.4 × 10−8
Monocyte count	0.055	2.2 × 10−87	132,212	0.063	5.9 × 10−243	396,820	0.060 (0.057, 0.064)	4.4 × 10−327	0.00012
Neutrophil count	0.042	8.2 × 10−66	132,200	0.062	2.9 × 10−270	396,820	0.055 (0.052, 0.058)	1.4 × 10−324	3.9 × 10−25
Triglycerides	0.025	9.7 × 10−9	96,081	0.020	2.4 × 10−29	390,346	0.021 (0.017, 0.024)	2.7 × 10−36	0.29
Total cholesterol	0.023	2.2 × 10−7	102,393	0.012	2.1 × 10−9	390,652	0.014 (0.010, 0.017)	3.2 × 10−14	0.024
Non-HDL cholesterol	0.021	4.2 × 10−6	96,881	0.013	3.5 × 10−9	358,461	0.015 (0.011, 0.018)	2.5 × 10−13	0.11
Heart rate	0.022	2.1 × 10−6	55,042	0.015	1.9 × 10−17	385,917	0.016 (0.013, 0.019)	5.9 × 10−22	0.16
Mean arterial pressure	0.009	0.041	76,003	0.013	1.2 × 10−12	385,914	0.012 (0.009, 0.016)	2.0 × 10−13	0.4
GGTP	0.031	2.1 × 10−14	101,537	0.031	7.4 × 10−60	390,457	0.031 (0.028, 0.034)	1.4 × 10−72	1
AP	0.020	2.8 × 10−6	102,035	0.018	2.3 × 10−21	390,671	0.018 (0.015, 0.022)	3.9 × 10−26	0.67
Bilirubin	−0.029	3.1 × 10−13	73,535	−0.013	4.5 × 10−17	389,085	−0.015 (−0.018, −0.012)	1.2 × 10−25	0.00018
CRP	0.013	5.7 × 10−5	115,557	0.019	2.2 × 10−24	389,840	0.018 (0.014, 0.021)	2.3 × 10−27	0.11
Creatinine	−0.019	1.3 × 10−6	136,328	−0.014	4.8 × 10−15	390,463	−0.015 (−0.018, −0.012)	6.6 × 10−20	0.25
Height	−0.055	6.6 × 10−20	74,992	−0.036	1.8 × 10−67	407,823	−0.038 (−0.042, −0.034)	1.1 × 10−83	0.0029
Weight	−0.027	2.9 × 10−8	76,546	−0.020	1.9 × 10−29	407,548	−0.021 (−0.024, −0.018)	8.9 × 10−36	0.18
RBC	−0.005	0.062	139,114	0.002	0.28	397,499	0.000 (−0.003, 0.003)	0.85	0.032

AP alkaline phosphatase, AS ankylosing spondylitis, BPH benign prostate hyperplasia, CRP C-reactive protein, E effect, GGTP gamma-glutamyl transpeptidase, MPN myeloproliferative neoplasm, MPV mean platelet volume, n number of individuals, nAff number of cases, nCon number of controls, P P value, P_het P value for heterogeneity in the effect estimate between the Icelandic and UK Biobank data, PLT platelet count, RA rheumatoid arthritis, RBC red blood cell count, WBC white blood cell count.

The applied significance threshold was a combined P value of 1 × 10⁻⁵ (see “Methods”). Only statistically significant associations are presented.