Table 2.

IC₅₀ values for responses normalized to the control (DMSO), calculated by fitting a dose–response curve model in Graph Pad Prism and tabulated as concentration of drugs in µM. In cases where responses were above the highest drug concentration used in the experiment, IC₅₀ estimates are marked as > 50 µM. Values in bold depict sensitive primary cells and cell lines, where IC₅₀ to compounds < 10 µM and R² (goodness of fit of curve) > 0.7).

	DNA repair		Hedgehog	Hippo		Cell cycle RB1
	Niraparib	Olaparib	Vismodegib	Verteporfin	Palbociclib	Alisertib	Volasertib	AZD7762
Cell line	PARP inhibitors		SMO inhibitor	YAP inhibitor	CDK4/6 inhibitor	Aurora kinase inhibitor	PLK1 inhibitor	CHEK1 inhibitor
Meso-27T	7.96	10.52	31.53	1.08	> 50	3.20	6.57	0.45
Meso-33T	47.02	> 50	6.03	0.87	20.29	3.84	0.10	0.45
Meso-70T	> 50	2.88	> 50	1.2	> 50	0.15	0.04	2.02
NCI-H2052	29	27.3	13.7	10.9	> 50	0.81	0.64	2.42
A549	> 50	13.47	20.72	16.5	12.33	11.7	0.71	1.84
Met-5A	> 50	11.13	8.53	3.36	29.2	> 50	0.44	0.11