Table 2.
Organ weight (mg) of neonates
| Organ | Control | Low | High |
|---|---|---|---|
| Kidney (left) | 22.4 ± 5.4 | 19.7 ± 3.4 | 24.9 ± 3.0* |
| Kidney (right) | 22.2 ± 6.4 | 21.0 ± 5.2 | 24.4 ± 2.4* |
| Thymus | 13.8 ± 4.9 | 13.0 ± 3.3 | 15.5 ± 3.8 |
| Lung | 87.5 ± 13.6 | 75.7 ± 12.8† | 94.0 ± 6.4 |
| Heart | 18.5 ± 1.7 | 18.5 ± 3.4 | 22.7 ± 2.9§ |
| Spleen | 19.3 ± 3.4 | 17.6 ± 4.8 | 24.2 ± 5.3§ |
| Brain | 226.0 ± 26.1 | 223.0 ± 31.2 | 230.0 ± 32.4 |
| Liver | 115.0 ± 20.2 | 104.0 ± 19.0 | 123.0 ± 28.1* |
| Stomach | 23.5 ± 7.0 | 23.5 ± 4.6 | 36.4 ± 43.3 |
| Intestine | 183.0 ± 56.1 | 179.0 ± 30.1 | 206.0 ± 19.1* |
Organ weight of neonates was measured at the time of sacrifice, PND7. Data are expressed as means ± standard deviations from 17 neonates for each group
Statistically significant differences (p < 0.05): *compared to the low administration group; †compared to the control and the high administration group; §compared to the control and the low administration group