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Schematic of signaling cascades involving 20-HETE in inflammation disease. ↑: up-regulation; ↓: down-regulation. IL, interleukin; LOX, MAPK/ERK, the mitogen-activated protein kinase/extracellular signal-regulated kinase; NF-κB, nuclear factor-kappa B; TNF-α, tumor necrosis factor alpha; EGFR, epidermal growth factor receptor, VEGF, vascular endothelial growth factor; ROS, reactive oxygen species; PI3K, phosphoinositide 3-Kinases.
