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. 2021 Sep 14;9:704683. doi: 10.3389/fcell.2021.704683

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Copyright © 2021 Wang, Zhang, Zhou, Chen, Xiang, Fan, Yu, Cai, Wu, Huang, He, Hu, Ding and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SMG1 is directly targeted by miR-1307-3p. (A) Overlapping of target genes of miR-1307-3p in TargetScan, Starbase, and miRTarBase. (B) Twenty-five potential genes were detected in control or circPPP1CB knockdown cells, and SMG1, WDR92, and PRPF4 were downregulated in both T24 and EJ. (C) Only SMG1 could induce the alternations of EMT markers and MMP2. (D) Luciferase reporter assay verified the interaction between SMG1 3’-UTR and miR-1307-3p. (E,F) A negative correlation between miR-1307-3p and circPPP1CB at mRNA level and protein level. *p < 0.05, **p < 0.01 vs. control group.