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. 2021 Sep 14;9:704683. doi: 10.3389/fcell.2021.704683

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Copyright © 2021 Wang, Zhang, Zhou, Chen, Xiang, Fan, Yu, Cai, Wu, Huang, He, Hu, Ding and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircPPP1CB suppresses tumor growth in vivo. (A) An equal number of control or circPPP1CB-overexpressing T24 cells were injected subcutaneously to establish xenograft tumors. After 28 days, tumors were harvested (n = 7 each group). (B,C) Tumor weight was determined when mice were sacrificed, and tumor volumes were measured and calculated every week. (D) HE staining and immunohistochemistry (IHC) detection of SMG1, MMP2, and EMT markers in tumors. (E) A graphical abstract illustrating that circPPP1CB inhibits bladder cancer tumorigenesis by interacting with miR-1307-3p and regulating SMG1 expression. *p < 0.05, **p < 0.01 vs. control group.