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. 2021 Sep 14;11:742949. doi: 10.3389/fonc.2021.742949

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Copyright © 2021 Ding, Chen, Lang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular trafficking pathway of PrP^C. PrP^C (green dot) is synthesized in ribosome attached to ER (endoplasmic reticulum). PrP^C is imported to ER where it will be glycosylated and modified by GPI anchor before it is transported into Golgi apparatus for further modification. Mature PrP^C is trafficked to plasma membrane and located there by its GPI anchor. Some mature PrP^C could be endocytosed for degradation in the lysosome or for being contained in exosomes and secreted outside the cell. PrP^C, Cellular prion protein; GPI, glycosylphosphatidylinositol.