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. 2021 Sep 14;11:742949. doi: 10.3389/fonc.2021.742949

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Copyright © 2021 Ding, Chen, Lang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PrP^C promotes cancer cell drug resistance. PrP^C can promote cancer cell drug resistance by promoting cell proliferation and inhibiting apoptosis. PrP^C can also suppress autophagy inhibiting or promoting drug resistance. HOP, Hsp70/90 organizing protein; IAPs, Inhibitors of apoptosis proteins; Glut1, Glucose transporter 1; PI3K, Phosphatidylinositide 3-kinase; AKT, Protein kinase B; Bax, Bcl-2-associated X protein; UPR, Unfolded protein response; SOD, Superoxide dismutase; P-gp, P-glycoprotein.