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. 2021 Sep 14;9:736935. doi: 10.3389/fcell.2021.736935

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Copyright © 2021 Li, Wu, Sui, Wang, Xu and Pang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of HM modifiers with their substrates, and the functions of HATs in BC. (A) Landscape of histone acetylation and methylation writers, erasers and their catalyzed substrates. (B) HATs promote BC proliferation, invasion and metastasis, drug-resistance, EMT, CSC properties and inhibit apoptosis by enhancing transcription of oncogenes, such as TINCR, MyD88, Cyclin D1, PI3KR1/P50, MDR1, MYH9, MYL9, CYR61, IL-6, and TWIST1. On the contrary, P300/CBP inhibit BC tumorigenesis, metastasis and CSC properties by enhancing transcription of TSGs, such as E-cadherin and BRCA1.