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. 2021 Sep 21;14(9):dmm047464. doi: 10.1242/dmm.047464

Fig. 3.

Fig. 3.

dAMN or dCubilin knockdown in nephrocytes shortens Drosophila lifespan, whereas dAMN overexpression in nephrocytes extends Drosophila lifespan. (A-F) Survival curves of flies with different genotypes. The data of each genotype was acquired from at least 190 individual replicates. The log rank test was used for significance testing. (A,B) RNAi knockdown of dAMN specifically in nephrocytes significantly shortened lifespan in male and female flies (average 57.1 days versus 64.6 days for male; average 53.5 days versus 63.1 days for female; P<0.05). (C,D) RNAi knockdown of dCubilin specifically in nephrocytes dramatically shortened lifespan in male and female flies (average 31 days versus 51.4 days for male; average 24.4 days versus 52.4 days for female; P<0.05). (E,F) Nephrocyte-specific dAMN overexpression significantly extended lifespan in male and female flies (average 67.9 days versus 62.4 days for male; average 76.7 days versus 61.9 days for female; P<0.05). Nephrocyte-specific overexpression of human AMN (hAMN) significantly extended lifespan in female flies (average 70.8 days versus 61.9 days, P<0.05).