TABLE 3.
Effects of toludesvenlafaxine on the Locomotor activity in olfactory bulbectomized rats.
| Group | Dose (mg/kg) | Moving distance (squares crossed) | Rearing time (seconds) | ||
|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 7 | Day 14 | ||
| Sham-operated a | - | 10.9 ± 3.0 | 14.7 ± 5.8 | 6.5 ± 2.5 | 7.4 ± 2.7 |
| Vehicle b | - | 29.3 ± 7.9c | 27.8 ± 7.4c | 15.7 ± 7.5c | 13.8 ± 3.7c |
| DVS b | 7.3 | 26.8 ± 7.6 | 26.7 ± 10.1 | 7.0 ± 3.1d | 9.4 ± 3.1d |
| Toludesvenlafaxine b | 4 | 22.6 ± 8.1e | 22.1 ± 8.8 | 5.1 ± 2.2d | 6.9 ± 2.0d |
| Toludesvenlafaxine b | 8 | 16.8 ± 4.2d | 15.6 ± 4.8d | 4.8 ± 2.0d | 5.0 ± 2.2d |
| Toludesvenlafaxine b | 16 | 10.6 ± 3.8d | 11.3 ± 3.5d | 4.2 ± 3.1d | 5.1 ± 2.8d |
DVS = O-desvenlafaxine succinate.
a
= no olfactory bulbectomy.
b
= olfactory bulbectomy.
c
p < 0.01 versus sham-operated group.
e
p < 0.05.
d
p < 0.01 versus vehicle group. Significance was determined by one-way ANOVA followed by Dunnett’s test. Values were presented as mean ± STD (n = 10).