TABLE 4.
Effects of toludesvenlafaxine on sugar consumption, serum corticosterone and testosterone levels in olfactory bulbectomized rats.
| Group | Dose (mg/kg) | Sugar consumption rate (%) | Corticosterone (ng/L) | Testosterone (ng/mL) |
|---|---|---|---|---|
| Sham-operated a | - | 75.8 ± 12.7 | 407.4 ± 216.5 | 4.7 ± 3.5 |
| Vehicle b | - | 49.7 ± 18.9c | 502.5 ± 102.0 | 1.7 ± 1.3 |
| DVS b | 7.3 | 58.1 ± 26.6 | 394.1 ± 231.6 | 2.4 ± 1.8 |
| Toludesvenlafaxine b | 4 | 62.1 ± 15.5 | 281.3 ± 118.8d | 2.0 ± 1.4 |
| Toludesvenlafaxine b | 8 | 70.7 ± 15.6d | 206.6 ± 91.2e | 3.3 ± 2.6 |
| Toludesvenlafaxine b | 16 | 73.4 ± 15.6e | 222.0 ± 99.6e | 5.4 ± 4.6d |
DVS = O-desvenlafaxine succinate.
a
= no olfactory bulbectomy.
b
= olfactory bulbectomy.
c
p < 0.01 versus sham-operated group.
d
p < 0.05.
e
p < 0.01 versus vehicle group. Significance was determined by one-way ANOVA followed by Dunnett’s test. Values were presented as mean ± STD (n = 10).