TABLE 5.
Blood, brain and hypothalamus tissue distribution of toludesvenlafaxine and ODV following intragastric administration of Toludesvenlafaxine at 8 mg/kg in Rats.
| Time | Brain (ng/g) | Hypothalamus (ng/g) | Blood (ng/mL) | |
|---|---|---|---|---|
| Toludesvenlafaxine | 15 min | 4.00 ± 4.38 | 68.6 ± 77.45 | 0.55 ± 0.48 b |
| 1 h | 1.45 ± 1.01 | 46.12 ± 41.44 | 0.34 ± 0.47 | |
| 12 h | 0.41 ± 1.17 | 2.56 ± 4.98 | 0.09 ± 0.26 | |
| ODV | 15 min | 13.78 ± 8.40 | 92.52 ± 68.23 | 90.89 ± 33.55 b |
| 1 h | 20.88 ± 6.80 | 97.88 ± 57.98 | 68.20 ± 23.56 | |
| 12 h | 2.06 ± 1.29 | 7.22 ± 6.79 | 2.84 ± 2.69 |
a
= hours; ODV = O-desmethyl venlafaxine.
ODV, the active metabolite of toludesvenlafaxine, following oral administration of toludesvenlafaxine at 8 mg/kg in rats.
b
the concentration was detected at 20 min after Toludesvenlafaxine administration by oral.