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. 2021 Sep 14;11:714440. doi: 10.3389/fcimb.2021.714440

Figure 1.

Figure 1

The pulmonary severity of IAV is not increased in T1DM versus control male C57BL/6J mice at six days post-infection. (A) Percentage of original body weight over infection course in IAV- or mock-infected mice with and without T1DM. (B) Arterial oxygen saturation percentage in IAV- or mock-infected mice with and without T1DM. (C) Lung IAV viral copy number in IAV- or mock-infected mice with and without T1DM. (D) Total lung histopathology scores in IAV- or mock-infected mice with and without T1DM. Data are pooled from two experiments, the initial containing six mice per group and the repeat containing 3 mice per group. Statistical outliers were removed by ROUTS test (Q=1%). For graph (A), each data point represents the mean ± SEM of at least n=9 mice per group, for graphs (B, C), each data point represents one mouse with median ± IQR of at least n=5 per group, and for graph (D), each data point represents one mouse with mean ± SEM of at least n=9 mice per group. Statistical analysis was performed as described in “Methods”, being performed on untransformed data for graphs (B, C) as transforming did not achieve closer-to-normal distribution.