Figure 4.

miR-876-5p regulates HCC cell proliferation, cell cycle, and invasion capacity. (A) CCK-8 and (B) EdU assays reveal that miR-876-5p mimics inhibited and inhibitor promoted the proliferation of HCC cells. (C) Flow cytometry reveals that miR-876-5p mimics induced cell cycle arrest, while, miR-876-5p inhibitor accelerated cell cycle. (D) Transwell assays reveal miR-876-5p mimics attenuated, while, inhibitor promoted the invasion of HCC cells. All the above experiments were repeated three times independently; data are presented as mean ± SD; statistical significance was assessed by Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001.