TABLE 1.
Single nucleotide polymorphisms (SNPs) associated with leptin levels [unadjusted and adjusted for BMI, µg/ml (log-transformation)] (Kilpeläinen et al., 2016) and their association with the risk for anorexia nervosa (AN) (OR is transformed to beta) (Watson et al., 2019).
| SNP | Gene | Chr | EA | OA | Leptin levels unadjusted for BMI | Leptin levels adjusted for BMI | AN | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EAF | B | se | p | F | b | se | p | b | se | p | |||||
| rs10487505 | LEP | 7 | G | C | 0.50 | 0.023 | 0.005 | 9.0E-06 | 21.16 | 0.029 | 0.004 | 2.0E-12 | −0.032 | 0.0135 | 0.0184 |
| rs6071166 | SLC32A1 | 20 | C | A | 0.37 | 0.027 | 0.006 | 6.6E-07 | 20.25 | 0.024 | 0.004 | 1.8E-08 | −0.029 | 0.0141 | 0.0378 |
| rs780093 | GCKR | 2 | C | T | 0.61 | 0.032 | 0.005 | 2.3E-10 | 40.96 | 0.024 | 0.004 | 3.8E-10 | −0.024 | 0.0138 | 0.0778 |
| rs8043757 | FTO | 16 | T | A | 0.40 | 0.030 | 0.005 | 1.1E-09 | 36.00 | 0.001 | 0.004 | 8.4E-01 | 0.023 | 0.0136 | 0.0925 |
| rs900400 | CCNL1 | 3 | T | C | 0.60 | 0.030 | 0.005 | 5.6E-09 | 36.00 | 0.021 | 0.004 | 1.2E-07 | −0.021 | 0.0136 | 0.1204 |
Font in italic: these effect sizes were used to assess the effect of BMI on leptin levels; Chr: chromosome; EA: effect allele; OA: other allele; b: effect size of EA; se: standard error; p: p-value; F: F-statistics.