TABLE 2.

Results of single SNP MR analyses and the overall causal effect of leptin levels (Kilpeläinen et al., 2016) on the risk for anorexia nervosa (AN) (Watson et al., 2019) calculated using different MR methods. The beta estimates the change in risk for AN (OR is transformed to beta) per change of 1 unit of leptin concentration (log-transformed µg/ml).

SNP and nearest gene		Effect of leptin levels on risk for AN (SNP n = 5)					Effect of leptin levels on risk for AN (the SNP rs8043757 was excluded)
		b	Se	p	Lower 95% CI	Upper 95% CI	b	se	p	Lower 95% CI	Upper 95% CI
rs10487505	LEP	−1.387	0.587	0.018			−1.387	0.587	0.018
rs6071166	SLC32A1	−1.089	0.522	0.037			−1.089	0.522	0.037
rs780093	GCKR	−0.759	0.431	0.078			−0.759	0.431	0.078
rs900400	CCNL1	−0.703	0.453	0.121			−0.703	0.453	0.121
rs8043757	FTO	0.760	0.453	0.094
MR Egger		2.635	3.375	0.492	−3.981	9.251	1.078	2.009	0.645	−2.859	5.016
Inverse variance weighted (IVW)		−0.546	0.369	0.139	−1.269	0.177	−0.923	0.244	1.5E-04	−1.401	−0.445
Simple median		−0.759	0.318	0.017	−1.383	−0.136	−0.924	0.328	0.005	−1.566	−0.282
Weighted median		−0.737	0.280	0.009	−1.287	−0.188	−0.790	0.298	0.008	−1.375	−0.206
Penalised weighted median		−0.785	0.307	0.011	−1.387	−0.183	−0.790	0.308	0.010	−1.395	−0.186
Simple mode		−0.913	0.352	0.060	−1.603	−0.223	−0.782	0.383	0.134	−1.533	−0.032
Weighted mode		−0.826	0.373	0.091	−1.556	−0.096	−0.761	0.373	0.134	−1.492	−0.029
MR RAPS		−0.700	0.319	0.028	−1.326	−0.074	−0.930	0.268	0.001	−1.455	−0.404
MR PRESSO outlier corrected		−0.923	SD = 0.148	0.008
		MR PRESSO global test p = 0.023; Eggers intercept = −0.091, SE = 0.096 p = 0.413; Heterogeneity test based on MR Egger: Q (df = 3) = 9.078 (df = 5), p = 0.028; based on IVW Q (df = 4) = 11.798, p = 0.019					MR PRESSO no outlier; Eggers intercept = −0.057, SE = 0.057, p = 0.421; Heterogeneity test based on MR Egger Q (df = 2) = 0.097, p = 0.953); based on IVW (Q (df = 3) = 1.105, p = 0.776

b: effect size; se: standard error; p: p-value; CI: confidence interval. Bolded values: p < 0.05.