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. 2021 Sep 14;12:674803. doi: 10.3389/fimmu.2021.674803

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Copyright © 2021 Li, Chen, Liu, Xiao, Xie, Geng, Zhang, Zhang, Lu, Tan, Li and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The clinical therapeutic significance of IL-17. IL-17 could boost deeper comprehend of AP and represents a novel immunotherapy for AP by targeting the Th 17 cell/IL-17 immune axis, including targeting Th17 pathway in AP, targeting IL-17 and its receptor in AP, inhibition of IL-17 synergistic cytokines and interdicting AP cascade reaction through gut microbiota. Continuous renal replacement therapy (CRRT), continuous veno-venous hemofiltration (CVVH) and high-volume hemofiltration (HVHF) effectively attenuates the Th17/Treg imbalance and clear serum IL-17 in SAP patients.