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. 2021 Sep 14;12:705539. doi: 10.3389/fimmu.2021.705539

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Copyright © 2021 Rodríguez-Martín, Rojas, Macchi, Franceschi, Russo, Sevilla, Donofrío and Martín

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical disease of immunized sheep following PPRV challenge. Following the clinical score proposed on (23) with slight modifications (17), the graded clinical observation for the development of disease after PPRV challenge in immunized sheep was represented. Data are presented as average (± SEM) score for different days post-challenge (dpi) for each treatment group as indicated in the legend. Differences were found to be significant (*p < 0.05; **p < 0.005; ***p < 0.0005; ****p < 0.00005; two-way ANOVA) between control (PBS or BoHV-4-A-ΔTK) and vaccinated group from days 3 to 8 post-challenge.