Skip to main content
. 2021 Sep 14;12:596686. doi: 10.3389/fphar.2021.596686

FIGURE 8.

FIGURE 8

BBH inhibited the EFS-induced contractile responses of isolated colonic longitudinal smooth muscles treated with P2Y1 receptor antagonist. Mechanical recording (A, B, and E–J), histogram (C,D), and line chart (K,L) of the inhibitory effect of BBH on the tension of the α,β-MeATP-treated and MRS2500-treated isolated colonic longitudinal smooth muscles in the control and IBS-D groups. (A): α,β-MeATP-treated (n = 24) and MRS2500-treated (n = 24) control groups. (B): α,β-MeATP-treated (n = 24) and MRS2500-treated (n = 24) IBS-D groups. (C): *denotes p < 0.05 compared with the α,β-MeATP-treated group. (D): # denotes p < 0.05 compared with the MRS2500-treated control group. (E) EFS-induced control group (n = 18). (F): IBS-D group (n = 14). (G): EFS + MRS2500-treated control group (n = 24). (H): EFS + MRS2500-treated IBS-D group (n = 29). (I): BBH + MRS2500-treated and EFS-induced control group (n = 25). (J): BBH + MRS2500-treated and EFS-induced IBS-D group (n = 14). (K): Inhibitory effect of BBH on the MRS2500-treated control group. (L): Inhibitory effect of BBH on the MRS2500-treated IBS-D group & denotes p < 0.05 compared with the EFS-induced IBS-D group. $ denotes p < 0.05 compared with the EFS + MRS2500-induced IBS-D group. Error bars represent mean ± SEM.