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. 2021 Sep 14;9:702974. doi: 10.3389/fcell.2021.702974

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Copyright © 2021 Raghunandan, Ramachandran, Ke, Miao, Lal, Chen and Subramaniam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HMOX1 is a key regulator of cell fate in HUVECs upon HP treatment. Significant transcription factor-target interactions were identified to determine key gatekeepers of cell fate and function. (A) Top 10 up-regulated transcription factors at 1-h post HP treatment. (B) The top 10 up-regulated gene targets of JUN family transcription factors. All JUN targets differentially expressed at least one-time points were identified and ranked by average fold-change across all time points. (C) Two genes were selected from (B) for a siRNA screen experiment: ATF3 and HMOX1. After 48 h of transfection and 6 h of HP treatment, HUVECs were imaged using phase-contrast microscopy (the images shown are the representative images taken from 3 repeats of the experiment; scale bars indicate 100 μm).