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. 2021 Sep 14;12:713567. doi: 10.3389/fphar.2021.713567

FIGURE 2.

FIGURE 2

In vitro transport activity of OATP2B1 genetic variants with substrates. Cellular accumulation of (A) estrone sulfate, (E1S) (1 μg/ml, n = 3), (B) dehydroepiandrosterone sulfate (DHEAS) (1 μg/ml, n = 4), (C) coproporphyrin (CP) I (1 μg/ml, n = 3), (D) CPIII (1 μg/ml, n = 3) and (E) rosuvastatin (1 μg/ml, n = 3) in HEK293T cells were transiently transfected with vector control (VC), OATP2B1 reference and OATP2B1 variants after incubation for 10 min (E1S, DHEAS, CPIII and rosuvastatin) or 30 min (CPI) in Krebs-Henseleit buffer (KHB) at pH 6. Results are shown as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.