. 2021 Sep 14;12:713567. doi: 10.3389/fphar.2021.713567

TABLE 1.

SLCO2B1 SNVs studied and their allele frequencies.

Designation	Nucleotide change	Protein change	CADD score^a	REVEL score^b	MetaLR score^b	Minor allele frequency^c
Designation	Nucleotide change	Protein change	CADD score^a	REVEL score^b	MetaLR score^b	Global	Caucasian	African	East asian
rs60113013	c.76_84del	p.Glu26_Thr28del	14.9	NA	NA	0.0293	0.0187	0.0032	0.1021
rs142693902	c.332G>A	p.Arg111Gln	27.8	0.632	0.436	0.0014	0.0007	0.0001	0.0000
rs35199625	c.601G>A	p.Val201Met	22.8	0.149	0.01	0.0198	0.0124	0.0022	0.0577
rs78825186	c.917G>A	p.Arg306His	9.4	0.111	0.141	0.0146	0.0226	0.0036	0.0001
rs12422149	c.935G>A	p.Arg312Gln	7.7	0.026	0	0.1759	0.1036	0.0910	0.3261
rs2306168	c.1457C>T	p.Ser486Phe	12.0	0.022	0	0.0826	0.0244	0.3365	0.2250

Combined Annotation Dependent Depletion (CADD) score was obtained from https://cadd.gs.washington.edu.

Rare Exome Variant Ensemble Learner (REVEL) and MetaLR score was obtained from https://m.ensembl.org.

Allele frequencies sourced from gnomAD database, https://gnomad.broadinstitute.org.

NA, not applicable.