TABLE 4.
Univariate Analyses of SLCO2B1 gene variants with circulating endogenous substrate concentrations.
| Variant | SLCO2B1 c.76-84del | SLCO2B1 c.601G>A | SLCO2B1 c.917G>A | SLCO2B1 c.935G>A | SLCO2B1 c.1457C>T | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Carrier statusa | NC | C | NC | C | NC | C | NC | C | NC | C |
| N | 88 | 5 | 90 | 3 | 88 | 5 | 72 | 21 | 76 | 17 |
| Estrone Sulfate (ng/ml) | 0.71 (±0.08) | 1.00 (±0.69) | 0.71 (±0.08) | 1.40 (±1.17) | 0.74 (±0.09) | 0.50 (±0.09) | 0.75 (±0.09) | 0.66 (±0.18) | 0.68 (±0.08) | 0.95 (±0.29) |
| DHEAS (ng/ml) | 1836 (±123) | 1,652 (±355) | 1827 (±120) | 1792 (±584) | 1856 (±122) | 1299 (±337) | 1721 (±138) | 2149 (±209) | 1701 (±121) | 2388* (±318) |
| Pregnenolone Sulfate (ng/ml) | 52 (±3) | 56 (±16) | 52 (±3) | 68 (±26) | 53 (±3) | 32 (±5) | 49 (±3) | 63 (±7) | 47 (±3) | 74** (±6) |
| CPI (nM) | 0.92 (±0.06) | 0.95 (±0.22) | 0.92 (±0.05) | 1.04 (±0.39) | 0.93 (±0.06) | 0.76 (±0.21) | 0.84 (±0.06) | 1.20** (±0.10) | 0.92 (±0.06) | 0.94 (±0.10) |
| CPIII (nM) | 0.12 (±0.01) | 0.12 (±0.02) | 0.12 (±0.01) | 0.15 (±0.02) | 0.12 (±0.01) | 0.08* (±0.01) | 0.11 (±0.00) | 0.16** (±0.01) | 0.11 (±0.01) | 0.14 (±0.01) |
a
NC, non-carrier; C, Carrier (heterozygotes + homozygotes).
Mean ± S.E.M.
*p < 0.05, **p < 0.01.