TABLE 5.

Multivariable linear regression models for circulating endogenous substrates of OATP2B1.

Model	Variable	Coefficient	p-Value
Log (Estrone Sulfate) (R2 = 0.047)	Intercept	−0.3522
	Sexa	−0.05838	0.5320
	SLCO2B1 c.935G>Ab	−0.02600	0.8227
	SLCO2B1 c.1457C>Tb	0.07600	0.5559
	SLCO1B1 c.388A>Gb	−0.07181	0.5051
	SLCO1B1 c.521T>Cb	0.2094	0.0525
Log (DHEAS) (R2 = 0.491)	Intercept	3.321
	Sexa	0.2882	<0.0001
	Age	−0.01091	<0.0001
	SLCO2B1 c.935G>Ab	0.06765	0.2898
	SLCO2B1 c.1457C>Tb	0.09664	0.1906
	SLCO1B1 c.388A>Gb	0.05940	0.3426
	SLCO1B1 c.521T>Cb	−0.01988	0.7349
Log (Pregnenolone Sulfate) (R2 = 0.451)	Intercept	1.809
	Sexa	0.1168	0.0121
	Age	−0.01001	<0.0001
	SLCO2B1 c.935G>Ab	0.02807	0.6161
	SLCO2B1 c.1457C>Tb	0.1624	0.0135
	SLCO1B1 c.388A>Gb	0.05564	0.1635
	SLCO1B1 c.521T>Cb	0.07223	0.3116
Log (CPI) (R2 = 0.271)	Intercept	−0.2455
	Sexa	0.1197	0.0063
	Racec	0.1109	0.1298
	SLCO2B1 c.935G>A b	0.1512	0.0093
	SLCO2B1 c.1457C>Tb	−0.06612	0.3692
	SLCO1B1 c.388A>Gb	0.05354	0.2836
	SLCO1B1 c.521T>Cb	0.07340	0.1387
Log (CPIII) (R2 = 0.340)	Intercept	−1.038
	Sexa	0.1084	0.0007
	Racec	0.07965	0.1410
	SLCO2B1 c.917G>Ab	−0.1452	0.0370
	SLCO2B1 c.935G>Ab	0.1164	0.0057
	SLCO2B1 c.1457C>Tb	−0.004622	0.9303
	SLCO1B1 c.388A>Gb	0.006791	0.8509
	SLCO1B1 c.521T>Cb	−0.01293	0.7182

^aMales compared to reference (Females).

^bCarriers (heterozygotes + homozygotes) compared to reference (Non-carriers).

^cEast Asian compared to reference (Caucasians).