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. 2021 Sep 14;9:711348. doi: 10.3389/fcell.2021.711348

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Copyright © 2021 Zhang, Li, Zhang, Cui, Shi, Zhao and Sheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of three molecular subtypes of head and neck squamous cell carcinoma (HNSCC) in The Cancer Genome Atlas (TCGA) discovery dataset. (A) Consensus matrix heatmaps (k = 3) of common core genes in The Cancer Genome Atlas (TCGA) cohort. (B) Kaplan–Meier curves of overall (left, OS) and progression-free (right, PFS) survival for HNSCC patients in different subtypes. (C) Heatmap of differentially activated pathways based on gene set variation analysis (GSVA) score and clinicopathological features of the three subtypes.