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. 2021 Sep 14;11:648637. doi: 10.3389/fonc.2021.648637

Table 3.

Multivariate analyses of factors based on the Cox regression model.

Outcomes Variables in the final model B SE HR (95%CI) P
DMFS
Tumor stage
 T1
 T2 -0.310 0.387 0.734 (0.343-1.568) 0.424
 T3 -0.695 0.272 0.499 (0.293-0.850) 0.011
 T4 -0.366 0.185 0.694 (0.483-0.997) 0.048
Node stage
 N0
 N1 -1.502 0.344 0.223 (0.113-0.437) <0.001
 N2 -1.854 0.248 0.157 (0.096-0.255) <0.001
 N3 -0.908 0.212 0.403 (0.266-0.612) <0.001
Induction chemotherapy
 CCRT
 IC+CCRT 0.405 0.168 1.500 (1.078-2.086) 0.016
Radiation duration
 ≤ 7 weeks
 > 7 weeks -0.362 0.165 0.696 (0.504-0.962) 0.028
LRRFS
Node stage
 N0
 N1 -1.346 0.481 0.260 (0.101-0.669) 0.005
 N2 -0.823 0.292 0.439 (0.248-0.779) 0.005
 N3 -0.603 0.284 0.547 (0.314-0.955) 0.034
Radiation duration
 ≤ 7 weeks
 > 7 weeks -0.637 0.190 0.529 (0.365-0.768) <0.001
PFS
Age (continuous) 0.011 0.005 1.011 (1.001-1.022) 0.037
Tumor stage
 T1
 T2 -0.622 0.297 0.537 (0.300-0.962) 0.036
 T3 -0.463 0.180 0.629 (0.442-0.895) 0.010
 T4 -0.565 0.131 0.568 (0.440-0.734) <0.001
Node stage
 N0
 N1 -1.299 0.266 0.273 (0.162-0.459) <0.001
 N2 -1.127 0.179 0.324 (0.228-0.460) <0.001
 N3 -0.634 0.169 0.530 (0.381-0.739) <0.001
Radiation duration
 ≤ 7 weeks
 > 7 weeks -0.382 0.117 0.682 (0.543-0.857) <0.001
OS
Age (continuous) 0.021 0.007 1.021 (1.008-1.035) 0.007
Tumor stage
 T1
 T2 -0.765 0.355 0.465 (0.232-0.932) 0.031
 T3 -0.942 0.233 0.390 (0.247-0.615) <0.001
 T4 -0.943 0.159 0.393 (0.288-0.536) <0.001
Node stage
 N0
 N1 -1.668 0.336 0.189 (0.098-0.364) <0.001
 N2 -1.404 0.210 0.246 (0.163-0.371) <0.001
 N3 -0.863 0.196 0.422 (0.287-0.620) <0.001
Radiation duration
 ≤ 7 weeks
 > 7 weeks -0.505 0.143 0.604 (0.456-0.799) <0.001

OS, Overall survival; DMFS, Distant metastasis–free survival; LRRFS, locoregional relapse–free survival; PFS, progression–free survival.