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. 2021 Sep 14;9:729965. doi: 10.3389/fcell.2021.729965

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Copyright © 2021 Dai, Sheng, Wang, Zhou, Lin, Du, Yang, Sha, Peng, Yao, Yin and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High hypoxia inducible factor-1α (HIF1α) staining is related with worse response of neoadjuvant therapy (NAT) containing paclitaxel and higher clinical stage in local advanced breast cancer (BC) cohort. (A) Bar plot showing NAT response and HIF1α staining results of each individual in Renji breast cancer NAT cohort. (B) Polymerase chain reaction (PCR) rate of NAT and ratio of patients reaching the AJCC stage III in different HIF1α expression groups. PCR, pathological complete response; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; NAT, neoadjuvant therapy.