TABLE 1.

Published developmental toxicity of compounds evaluated in zebrafish.

Time	Laboratory	Zebrafish lines	Exposure period	Evaluation index	Predictability/test compounds	Notes
2011	OECD	–	Newly fertilized eggs were exposed for 96 h	Coefficients of variation, LC50	–/7	Experiments were evaluated in 7 laboratories
2012	OECD	–	Newly fertilized eggs were exposed for 96 h	Coefficients of variation, LC50	–/13	Experiments were evaluated in 4 laboratories
2012	AstraZeneca et al.	Wild type and WIK strain	6 hpf-5 dpf	Morphological scoring, LC25, LOAEL, NOAEL	60–70%/20	Experiments were evaluated blinded in 4 laboratories
2012	FITR*	Wild type	2 hpf-6 dpf	TI(= LC50//EC50)	50–60%/27	Experiments were conducted for 3 times
2012	Phylonix, Cambridge et al.	–	6 hpf-5 dpf	TI(= LC50//EC50)	92%/12	–
2014	AstraZeneca et al.	Wild type	6 hpf-5 dpf	Morphological scoring, LOAEL, TI(= LC25/NOAEL)	62–82%/38	Experiments were evaluated blinded in 2 laboratories
2014	FDA	Hb9: GFP transgenic zebrafish	24 hpf-52 hpf	Body length, fiber length	–/5	–

^*Flemish Institute for Technological Research.