TABLE 4.
Developmental toxicity results of negative controls (non-teratogen) compounds in zebrafish.
| Compound |
2 dpf
|
5 dpf
|
Teratogenicity in zebrafish
|
Correct prediction | |||||
| LC25 (μM) | NOAEL(μM) | TI | LC25 (μM) | NOAEL(μM) | TI | Before optimization | After optimization | ||
| Chlortalidone | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Hydrochlorothiazide | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Vildagliptin | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Progesterone | >10 | >10 | 1 | >10 | >10 | 1 | N | N | √ |
| Cetirizine hydrochloride | >100 | >100 | 1 | >100 | >100 | 1 | N | N | √ |
| Cyproheptadine hydrochloride | >10 | 1 | >10 | 10 | 1 | 10 | FP | FP | × |
| Doxylamine succinate | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Metoclopramide | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Nizatidine | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Clindamycin hydrochloride | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Erythromycin | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Amoxicillin | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Sulfasalazine | >1000 | >1000 | 1 | >1000 | >1000 | 1 | N | N | √ |
| Cyclobenzaprine hydrochloride | >1000 | >1000 | 1 | >100 | 10 | >10 | FP | FP | × |
N = no, FP = false positive. √: correct prediction; × : incorrect prediction.