Table 5.

Transcripts significantly enriched in each human endocrine subtype, as determined by scRNA-seq^a

	α	β	δ	γ	ε
Hormones, secreted factors	CRH, GCG	ADCYAP1, BMP5, IAPP, IGF2, INS	AQP3, FFAR4, GABRB3, LEPR, MS4A8, SLC17A6, UNC5B	ABCC9, CHRM3, FGFR1, NPFFR2, SLC6A4	ASGR1
Receptors, membrane transport	DPP4, FXYD3, FXYD5, FXYD6, KCNJ6, LAPTM4B, SDC2, SLC22A17, SLC38A4, SLC40A1, SLC7A2	CASR, KCNK16, ROBO1, ROBO2, SLC6A6	CD9, PARVB, SERPINA1	CPB1, PCDH10, SCGB2A1, SPOCK1, THSD7A
Basement membrane/ ECM/ adhesion- related	CD99L2, FAP, MUC13, NPNT, PAPPA2, SMOC1, SPOCK3, TM4SF4	TFF3, TIMP2, PVRL3	EHF, HHEX, NCOA7, PSIP1	ETV1, FOXP2, ID4, MAF, MEIS2, PAX6	SERPINA1, TM4SF5
Transcription factors or regulators	ARX, CBX6, HMGB3, IRX2, MAFB	BHLHE41, CDKN1A, CDKN1C, EIF4A2, HOPX, ID1, MAFA, NKX6-1, PDX1, RPB4, SAMD11	AKAP12, RBP4, TPPP3	AKAP9, TUBB2A
Motility, scaffold, transport	CLU, COTL1, GC, KCTD12, PALLD	FAM159B, GSN, SYNE2	PRG4	PDK4
Metabolism or lipid-related	ETFDH, FABP5, HIGD1A, PPP1R1A, PLCE1, PLIN3, SPTSSB	ERO1LB, G6PC2, HADH, SCD5	BCHE, RGS2, SEC11C	CHN2, DPYSL3	ACSL1
Miscellaneous enzymes	CHID1, F10, FSTL5, GLS, GPX3, LOXL4, PCSK2, RGS4, SERPINE2, TTR	ENTPD3, GPX2, PCSK1, PFKFB2, PRSS23, RRAGD, RASD1, RGS16	LINC00643, LY6H, UCP2	CMTM8, FGD4, PXK, SERTM1, STMN2
Other	ARRDC4, CFC1, CRYBA2, FAM84A, GADD45G, NUCB1, TMEM176A, TMEM176B	ASB9, DLK1, LMO1, MEG3, MT1F, NPTX2, SCGN, SYT13			ANXA13, PHGR1

Abbreviations: ECM, extracellular matrix.

^aSelected genes from lists reported by ≥2 individual studies: references (31-33, 269); (270) for ε cells only. Please note that sequencing and analysis methods differed among studies and thus the list is not exhaustive (n = 4 studies queried for α, β, δ, and γ cells; n = 3 for ε cells).