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. 2021 Sep 14;12:732345. doi: 10.3389/fphar.2021.732345

TABLE 3.

Absolute, relative, and average annual changes in the trends of opioids and gabapentinoids-related mortality and its association with their utilisation patterns across England, Scotland, Wales and Northern Ireland over the study period from 2010 to 2018.

England Scotland Wales Northern Ireland
Opioids-related mortality
 Absolute change (relative % change) 23.6 (42.4%) 165.7 (144.8%) 20.6 (25.3%) 59.9 (68%)
 Annual average change 3.6a 19.6a 3.4 7.0a
 Pearson correlation coefficient 0.84a 0.78a 0.42 0.87a
Gabapentinoids -related mortality
 Absolute change (relative % change) 4.5 (4,734%) 73.9 (12,963%) 6.7 (2,062%) 31.4 (2,868%)
 Annual average change 0.6a 8.7a 1.3a 6.0a
 Pearson correlation coefficient 0.97a 0.91a 0.94a 0.77a
a

(Note): Indicates p-value < 0.05.