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. 2021 Sep 28;30(11):1955–1980. doi: 10.1007/s00044-021-02787-6

Table 2.

A synopsis of the SARs associated with indole substitution patterns in HIV-1 AIs

graphic file with name 44_2021_2787_Tabc_HTML.gif
Compd R1 R2 R3 R4 EC50 (nM) CC50 (μM)
15 F H H H 2.6 >300
27 Cl H H H 4.3 212
28 CH3O H H H 0.52 >300
29 CH3CH2O H H H 0.45 >95
30 iPrO H H H >500 150
31 H F H H 838.3 >300
32 H Cl H H 395 46
33 H CH3O H H 21,100 >300
34 H H F H 21.1 >245
35 H H Cl H 208 >110
36 H H CH3O H 328.8 >300
37 H H H F 7.3 >152
38 H H H Cl 4.4 162
39 H H H CH3O 6.6 153
40 F H H F 0.35 >300
41 F H H CH3O 0.06 >300
42 CH3O H H CH3O 0.23 279
43 CH3O H H Cl 0.07 >300