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A synopsis of the effect of piperazine substitution or replacement on antiviral activity of 4-fluoro-substituted indole 3-glyoxamide derivatives [21]
 | |||
|---|---|---|---|
| Compd # |  |
EC50 (nM) | CC50 (μM) |
| 15 |  |
2.6 | >300 |
| 62 |  |
0.56 | >300 |
| 63 |  |
<0.16 | >300 |
| 64 |  |
1.38 | >300 |
| 65 |  |
2.60 | >300 |
| 66 |  |
>50,000 | >300 |
| 67 |  |
>50,000 | >300 |
| 68 | NH-CH2-CH2NH | >50,000 | >300 |
| 69 | CH3N-CH2-CH2N-CH3 | >50,000 | >300 |
| 70 | NH-CH2-CH2-CH2NH | >50,000 | >300 |
| 71 | CH3N-CH2-CH2-CH2-NCH3 | >50,000 | >300 |
| 72 |  |
>50,000 | >300 |
| 73 |  |
30,500 | 65 |
| 74 |  |
>50,000 | >300 |
