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SARs associated with C-4, C-7-disubstituted 6-azaindole derivatives
 | ||||
|---|---|---|---|---|
| R | R1 | EC50 (nM) | CC50 (μM) | |
| 172 | OCH3 |  |
0.02 | >150 |
| 173 | Fa | 0.05 | 8.06 | |
| 174 | OCH3 |  |
0.12 | 36 |
| 175 | OCH3 |  |
0.78 | >300 |
| 176 | F | 0.05 | >300 | |
| 177 | OCH3 |  |
0.21 | >300 |
| 178 | F | 0.07 | >300 | |
| 1 | OCH3 |  |
0.14 | >300 |
| 179 | F |  |
6.0 | >300 |
| 180 | OCH3 |  |
0.11 | >300 |
| 181 | OCH3 |  |
0.41 | >300 |
| 182 | F |  |
0.06 | >300 |
