Table 9.

Antiviral activity in the pseudotyped assay and rat PK parameters associated with 1 and 176

	1	176
Pseudovirus EC50 (nM)	0.14	0.05
Rat F (%)	82	64
AUC 24 h (μM.h)	111 ± 25	86 ± 33
IV CL (mL/min/kg)	1.3 ± 0.19	1.6 ± 0.2
IV t 1/2 (h)	4.3 ± 1.1
Vss IV (L/kg)	0.36 ± 0.098	0.49 ± 0.26

Dosed at 1 mpk IV and 5 mpk PO