TABLE 2.

Pharmacokinetic parameters in male and female rats after a single administration of Na-DHA.

	t1/2 (h)	tmax (h)	Cmax (mg/L)	AUC (mg/L*h)	Vz (L/kg)	Cl (L/h/kg)	MRT (h)
♂	18.94 ± 4.27	0.85 ± 0.32	322.19 ± 25.09	7556.82 ± 1537.91	0.51 ± 0.01	0.02 ± 0.01	25.59 ± 6.36
♀	23.22 ± 4.55*	1.03 ± 0.82	406.94 ± 7.92*	13781.96 ± 1405.43*	0.36 ± 0.03*	0.01 ± 0.00	33.55 ± 5.58*

Note: Na-DHA (200 mg/kg) was singly administered to the rats, and blood samples were collected at different time points during 0∼24 h. Pharmacokinetic parameters were analyzed using WinNonlin5.3 software based on the plasma Na-DHA concentration in six male or six female rats, as determined by HPLC.

*p < 0.05, compared to that in males.