Table 2.
Secondary metabolite and antibiotic gene clusters identified from P. mediterranea EDOX using antiSMASH 6.0 and BAGEL4.
| BGCs cluster | Type | Most similar known BGCs | MIBiG BGC ID | Mass spectrometry Identification (supernatant of EDOX) |
|---|---|---|---|---|
| 1 | Type I PKs-NRPs hybrid | Lankacidin C (13% of genes show similarity) | BGC0001100 | not detected |
| 2 | NRPs | Syringomycin (100% of genes show similarity) | BGC0000437 | Cormycins (Strano et al., 2015) |
| 3 | NRPs | Syringopeptin (100% of genes show similarity) | BGC0000438 | edox-1, edox-2* |
| 4 | Siderophore | - | - | not detected |
| 5 | NRPs | Anikasin (22% of genes show similarity) | BGC0001509 | not detected |
| 6 | Type I PKs-NRPs hybrid | Entolysin (17% of genes show similarity) | BGC0000344 | not detected |
| 7 | NRPs | Crochelin A (15% of genes show similarity) | BGC0002001 | not detected |
| 8 | Other | Fengycin (13% of genes show similarity) | BGC0001095 | not detected |
| 9 | Other | - | - | not detected |
| 10 | RiPP | - | - | not detected |
| 11 | Other | APE Vf (45% of genes show similarity) | BGC0000837 | not detected |
| 12 | NRPs | Fragin (37% of genes show similarity) | BGC0001599 | not detected |
Hyphens (−) were indicating that no similarity was found with known biosynthetic gene clusters (BGCs) in MIBiG repository.
*
edox-1 and edox-2 were later renamed as medipeptin A and medipeptin B.